{"id":35215,"date":"2023-10-10T19:20:04","date_gmt":"2023-10-10T19:20:04","guid":{"rendered":"https:\/\/danielsmarketingblc.com\/CuratedProducts\/?p=35215"},"modified":"2023-10-10T19:20:05","modified_gmt":"2023-10-10T19:20:05","slug":"macrophages-play-a-central-role-in-intestinal-cell-renewal-study-reveals","status":"publish","type":"post","link":"https:\/\/danielsmarketingblc.com\/CuratedProducts\/2023\/10\/10\/macrophages-play-a-central-role-in-intestinal-cell-renewal-study-reveals\/","title":{"rendered":"Macrophages play a central role in intestinal cell renewal, study reveals"},"content":{"rendered":"<div id=\"body-144194ff-adf3-42fa-97fb-f67292fac47d\" itemprop=\"articleBody\">\n<p>A research team from MedUni Vienna and the FWF-sponsored Special Research Area SFB F83 Immunometabolism has now demonstrated for the primary time the central role of macrophages within the renewal of intestinal cells, which sheds light on the complex interplay between immune cells and tissue regeneration. Particularly, it could possibly be described that macrophages produce the metabolites spermidine and spermine in high amounts, which then profit the opposite tissue cells within the organ. Consequently, the tissue cells not need to supply these substances themselves and are higher in a position to perform their proper functions. This primary description of a &#8220;commensal metabolism&#8221; of macrophages was recently published within the journal &#8220;Cell Metabolism&#8221;.<\/p>\n<p>The intestine, which is chargeable for digesting food and absorbing nutrients, relies on a single layer of epithelial cells (surface cells) to take care of the integrity of the intestinal barrier. These cells are completely renewed every 4 to seven days. This process is critical to protecting the body from microbial threats, maintaining intestinal function, and stopping diseases equivalent to inflammatory bowel disease and colon cancer.<\/p>\n<p>Macrophages are immune cells which are present in every organ of the body. The research team, led by Thomas Weichhart of MedUni Vienna&#8217;s Center for Pathobiochemistry and Genetics and coordinator of the SFB Immunometabolism, discovered that macrophages within the colon are strategically positioned in close proximity to intestinal epithelial cells. The researchers identified a vital mechanism by which these macrophages support the proliferation of epithelial cells. This metabolic support was particularly essential in periods of proliferative stress, equivalent to inflammation-related colitis.<\/p>\n<p>First writer of the study Stephanie Fritsch comments: &#8220;We were in a position to show that macrophages produce large amounts of the polyamines spermidine and spermine via the mTORC1 signaling pathway&#8221;. These polyamines were taken up by the epithelial cells, resulting in a switch of their cell metabolism, promoting their proliferation and strengthening their defense mechanisms. Spermine specifically had a serious stimulatory effect on the proliferation of colon cells. Importantly, this mTORC1 activation and polyamine production had a protective effect against inflammatory bowel injury in animal models. Polyamines especially spermidine have been heavily researched for a while as studies show that these substances can lengthen life and decelerate the aging process.<\/p>\n<p><!-- end mobile middle mrec --><\/p>\n<h2>Macrophages support the metabolism of other cells<\/h2>\n<p>This research represents a paradigm shift in understanding the gut microenvironment. It highlights macrophages for the primary time as &#8220;metabolic factories&#8221; that support the metabolism of other cells, which is critical for efficient self-renewal of the intestinal epithelium. As well as, the study offers insights into potential therapeutic targets for inflammatory bowel disease and other disorders related to gut dysfunction.<\/p>\n<h2>Paving the best way for brand spanking new therapies for tissue regeneration and intestinal diseases.<\/h2>\n<p>Thomas Weichhart says: &#8220;Because of the support of the FWF throughout the framework of this special research area, these findings have change into possible.&#8221; SFB F83 Immunometabolism includes groups from Vienna and Graz which are investigating the metabolic interaction of tissue cells and macrophages. The outcomes of this study open promising avenues for future research. Researchers may investigate the manipulation of macrophage-mediated metabolic support as a method to reinforce tissue regeneration and combat intestinal diseases. As well as, further investigation of the role of polyamines and mTORC1 signaling in immune cells may reveal latest therapeutic approaches.<\/p>\n<blockquote>\n<p>The outcomes represent a big step forward in our quest to raised understand the gut and improve human health.&#8221;<\/p>\n<p style=\"text-align: right;\">Thomas Weichhart of MedUni Vienna&#8217;s Center for Pathobiochemistry and Genetics and coordinator of the SFB Immunometabolism<\/p>\n<\/blockquote>\n<div id=\"sources\" class=\"content-source below-content-common-a\">\n<p>Source:<\/p>\n<div class=\"content-src-value\">\n<p><a href=\"https:\/\/www.meduniwien.ac.at\/web\/en\/about-us\/news\/2023\/news-in-october-2023\/immune-cells-identified-as-metabolic-factories-in-the-gut\/\" target=\"_blank\" rel=\"noopener\">Medical University of Vienna<\/a><\/p>\n<\/div>\n<p>Journal reference:<\/p>\n<div class=\"content-src-value\">\n<p>Fritsch, S. D., <em>et al<\/em>. (2023). Metabolic support by macrophages sustains colonic epithelial homeostasis. <em>Cell Metabolism<\/em>. <a href=\"https:\/\/doi.org\/10.1016\/j.cmet.2023.09.010\" target=\"_blank\" rel=\"noopener\">doi.org\/10.1016\/j.cmet.2023.09.010<\/a>.<\/p>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>A research team from MedUni Vienna and the FWF-sponsored Special Research Area SFB F83 Immunometabolism has now demonstrated for the primary time the central role of macrophages within the renewal of intestinal cells, which sheds light on the complex interplay between immune cells and tissue regeneration. Particularly, it could possibly be described that macrophages produce 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