{"id":31300,"date":"2023-07-14T01:05:25","date_gmt":"2023-07-14T01:05:25","guid":{"rendered":"https:\/\/danielsmarketingblc.com\/CuratedProducts\/?p=31300"},"modified":"2023-07-14T01:05:26","modified_gmt":"2023-07-14T01:05:26","slug":"macrophages-may-play-a-serious-role-in-the-event-of-atrial-fibrillation","status":"publish","type":"post","link":"https:\/\/danielsmarketingblc.com\/CuratedProducts\/2023\/07\/14\/macrophages-may-play-a-serious-role-in-the-event-of-atrial-fibrillation\/","title":{"rendered":"Macrophages may play a serious role in the event of atrial fibrillation"},"content":{"rendered":"<div id=\"body-67a46ac2-1bd2-4a1e-9702-5a5a5ba6f21e\" itemprop=\"articleBody\">\n<p>Current treatments for atrial fibrillation (AFib), a standard heart condition characterised by fast and irregular beats that may result in stroke and heart failure, have multiple unintended effects and are ineffective for stopping AFib reoccurrence.<\/p>\n<p>Latest research led by investigators at Massachusetts General Hospital (MGH) and published in <em>Science<\/em> reveals that certain immune cells play a serious role in the event of AFib. Targeting these cells may subsequently represent a promising technique to treat and stop AFib.<\/p>\n<p>For the work, senior writer Matthias Nahrendorf, MD, PhD, an investigator in MGH&#8217;s Center for Systems Biology and the Richard Moerschner Endowed MGH Research Institute Chair in Men&#8217;s Health, and colleagues analyzed single cells from atrial heart tissue collected from patients with and without AFib. The analyses indicated that immune cells called macrophages are essentially the most dynamic cell population within the atria during AFib, and these cells expand greater than another cell type in diseased tissue.<\/p>\n<p>The researchers also created a brand new mouse model of AFib they dubbed &#8220;HOMER&#8221; and tested if and the way macrophages could cause AFib.<\/p>\n<blockquote>\n<p>We found that recruited macrophages support inflammation and fibrosis, or scarring, of the atria, which hinder electrical conduction between heart cells and result in AFib. Inhibiting macrophage recruitment reduced AFib.&#8221;<\/p>\n<p style=\"text-align: right;\">Matthias Nahrendorf, MD, PhD, Investigator, MGH&#8217;s Center for Systems Biology<\/p>\n<\/blockquote>\n<p>Gene expression analyses revealed that in human and mouse hearts, the <em>SPP1<\/em> gene is extremely overexpressed in macrophages during AFib. This gene produces the SPP1 protein (also called osteopontin) that promotes tissue scarring and is elevated within the blood of patients with AFib. HOMER mice lacking this protein had reduced numbers of atrial macrophages.<\/p>\n<p><!-- end mobile middle mrec --><\/p>\n<p>Future therapeutic strategies for AFib could subsequently goal macrophages or macrophage-derived signals akin to SPP1 that contribute to inflammation and fibrosis. &#8220;We predict that this research lays the groundwork for immunomodulatory therapy of AFib, and we&#8217;re currently working on several strategies to make this occur,&#8221; says Nahrendorf.<\/p>\n<p>It should even be necessary to check how these strategies might complement current care. &#8220;By mapping cardiac and immune cells involved in atrial fibrillation, this research advances next steps toward studying how macrophage-targeted therapies may support existing treatment,&#8221; says Michelle Olive, PhD, the deputy chief of the Atherothrombosis and Coronary Artery Disease Branch inside the Division of Cardiovascular Sciences on the National Heart, Lung, and Blood Institute.<\/p>\n<p>Additional co-authors include Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong,\u2028Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, and Kamila Naxerova.<\/p>\n<p>This work was supported by the National Institutes of Health, the American Heart Association, Deutsche Forschungsgemeinschaft, Mercator fellow, DFG, British Heart Foundation, NIHR Oxford Biomedical Research Centre, and European Union MAESTRIA 965286.<\/p>\n<p>The National Institutes of Health (NIH) provided partial support for this research, but the discharge doesn&#8217;t represent the official views of NIH.<\/p>\n<div id=\"sources\" class=\"content-source\">\n<p>Source:<\/p>\n<div class=\"content-src-value\">\n<p><a href=\"https:\/\/www.massgeneral.org\/news\/press-release\/targeting-immune-cells-treat-atrial-fibrillation\" target=\"_blank\" rel=\"noopener\">Massachusetts General Hospital<\/a><\/p>\n<\/div>\n<p>Journal reference:<\/p>\n<div class=\"content-src-value\">\n<p>Hulsmans, M., <em>et al.<\/em> (2023) Recruited macrophages elicit atrial fibrillation. <em>Science<\/em> <a href=\"http:\/\/doi.org\/10.1126\/science.abq3061\" target=\"_blank\" rel=\"noopener\">doi.org\/10.1126\/science.abq3061<\/a>.<\/p>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Current treatments for atrial fibrillation (AFib), a standard heart condition characterised by fast and irregular beats that may result in stroke and heart failure, have multiple unintended effects and are ineffective for stopping AFib reoccurrence. Latest research led by investigators at Massachusetts General Hospital (MGH) and published in Science reveals that certain immune cells play 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