Small molecules called immunomodulators can assist create simpler vaccines and stronger immunotherapies to treat cancer. But finding the molecules that instigate the correct immune response is difficult -;the variety of drug-like small molecules has been estimated to be 1060, much higher than the variety of stars within the visible universe. In a possible first for […]
Glioblastoma, essentially the most common and deadly type of brain cancer, grows rapidly to invade and destroy healthy brain tissue. The tumor sends out cancerous tendrils into the brain that make surgical tumor removal extremely difficult or inconceivable. Now, Salk scientists have found the immunotherapy treatment anti-CTLA-4 results in considerably greater survival of mice with […]
“Don’t eat me!” That is how one might translate the signal that the cancer cells in a glioblastoma send to the macrophages (white blood cells specialized in removing dead and dying cellular matter) within the brain. Immunotherapy attempts to enable these cells to eradicate the abnormal cells, but to date, it has met with little […]